Understanding the Differences Between GLP-1 Medication Injections and Sublingual Droplets
GLP-1 (glucagon-like peptide-1) medications have revolutionized the way patients approach weight loss and metabolic health. These medications are available in two common forms: injections and sublingual droplets. Each has unique characteristics, benefits, and considerations, allowing patients to choose the option that best fits their lifestyle and preferences.

GLP-1 Injections
GLP-1 injections are one of the most well-established and widely used methods of administering these medications. Here's a closer look at their features:
How They Work:
The injections are typically administered once a week using a pre-filled pen or insulin syringes. They deliver the medication directly into the subcutaneous tissue, where it is absorbed into the bloodstream over time.
Benefits:
-
Convenience: With once-weekly dosing, injections are simple to incorporate into a routine.
-
Consistency: Injections provide a steady and reliable absorption rate, ensuring consistent therapeutic effects.
-
Proven Effectiveness: Injectable GLP-1 medications have been extensively studied and are highly effective for weight loss and improving blood sugar levels.
Considerations:
-
Needle Use: Patients must be comfortable with self-administering an injection, although the process is straightforward and minimally invasive.
-
Storage: Many injectable medications are stored in pressurized vials that require preparation with alcohol wipes, syringes, and needles in order to draw up the medication for injection. The medication can not pre-drawn up and stored within the syringes if traveling on an airplane or through high pressure areas, as the change in pressure will result in the non-sealed syringes to push out the medicine. This can be a factor for those with a busy or travel-heavy lifestyle, and require them to travel with the vial and all of the supplies while keeping the vial cold as the medication is usually required to be refrigerated.

Sublingual Droplets
Sublingual GLP-1 medications are a newer, needle-free option. They are designed for patients who prefer an alternative to injections.
How They Work:
Sublingual droplets are administered under the tongue. The medication is absorbed through the mucous membranes, entering the bloodstream directly.
Benefits:
-
Needle-Free: Ideal for individuals who are uncomfortable with injections or have a fear of needles.
-
Ease of Use: Sublingual administration is quick and straightforward, with no preparation or equipment needed.
-
Portability: The medication is still usually required to be refrigerated, but traveling with the sealed dropper vial is easier than injectable medications. Sublingual droplets are compact and easy to carry, making them a convenient option for travel without worrying about additional or separate supplies.
Considerations:
-
Frequency: Sublingual medications may need to be taken daily, requiring more frequent dosing compared to weekly injections. This can make it difficult to maintain therapeutic levels of the medication within the body if any dosages are missed or skipped.
-
Absorption Variability: Absorption rates may vary based on factors such as oral health or saliva production. This can be one of the biggest reasons for variability in results, as many patients do not hold the medication droplets long enough under their tongue for enough of the medication to be absorbed.
-
Limited Research: While promising, sublingual GLP-1 medications are relatively new and may not have as extensive a research base as injectables.
Choosing the Right Option
Selecting between GLP-1 injections and sublingual droplets depends on your individual preferences, medical history, and lifestyle. Here are some factors to consider:
-
Comfort Level: If you’re uneasy with needles, sublingual droplets may be a better fit.
-
Dosing Frequency: If you prefer less frequent dosing, weekly injections might be more convenient.
-
Medical Guidance: Always consult with your healthcare provider to determine which option is best suited to your needs and health goals.
Conclusion
Both GLP-1 injections and sublingual droplets offer effective ways to support weight loss and improve metabolic health. Understanding their differences can help you make an informed decision and embark on a treatment plan that works for you.
Talk to our provider, Jenny Vu, on a Free Introduction Call today to explore your options and take the first step toward achieving your health goals.
Or check out our Plans & Pricing page to review our pricing, make your purchase, and start your weight loss journey!